FIELD: pharmaceuticals.
SUBSTANCE: invention relates to a conjugate of general formula: Ama-L-X-S-Ab, in which Ama is an amatoxin, L is a linker, X is a fragment obtained by binding a thiol group with a thiol-reacting group, S is a sulfur atom of an amino acid residue of cysteine and Ab is an antibody sequence or a functional antibody fragment containing said cysteine residue, wherein said cysteine residue is 265Cys with a heavy chain in accordance with an EC numbering system, and wherein one or more one molecules of amatoxin are bound to one antibody or to one functional antibody fragment. What is also presented is a pharmaceutical composition and a method for production thereof.
EFFECT: conjugate is intended for treating tumorous diseases.
12 cl, 14 dwg, 1 tbl, 28 ex
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