FIELD: biotechnology.
SUBSTANCE: group of inventions including a conjugate of a non-natural amatoxin with an antibody having antitumor or anticancer activity, and the use of the conjugate for the production of an antitumor drug or an anticancer drug are described. In one embodiment, the conjugate has the structural formula (I).
EFFECT: invention expands the arsenal of agents with antitumor or anticancer activity.
13 cl, 4 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AMANTINE CONJUGATE WITH ANTIBODY | 2018 |
|
RU2809116C2 |
| AMATHOXINE-ANTIBODY CONJUGATES | 2016 |
|
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| NEW METHOD FOR SYNTHESIS OF AMANITINES | 2018 |
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| AMATOXIN CONJUGATES WITH IMPROVED BONDS | 2012 |
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| LINKER FOR ANTIBODY-DRUG CONJUGATES AND THEIR USE | 2019 |
|
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| SYNTHESIS METHODS OF AMATOXIN STRUCTURAL BLOCK AND AMATOXINS | 2013 |
|
RU2637924C2 |
| DELIVERY SYSTEMS FOR CONTROLLED DRUG RELEASE | 2016 |
|
RU2748992C2 |
