METHOD FOR INDIVIDUAL SELECTION OF SUPPORTING DOSE OF LEVOSIMENDAN FOR TREATING ACUTE HEART FAILURE IN ELDERLY PATIENTS IN ACUTE PHASE OF MYOCARDIAL INFARCTION Russian patent published in 2016 - IPC A61B5/00 

Abstract RU 2601666 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to cardiology. Sequential pharmacological test is performed and blood pressure (BP) and heart rate (HR) are measured and electrocardiogram (ECG) is analyzed. Pharmacological test is carried out in three stages. First stage involves introduction of a loading bolus of 4 mcg/kg of levosimendan for 10 minutes which is equal to 1/3 of the standard value and if BP is not less than 100 mm Hg, HR is not more than 100 beats per minute, paroxysmal atrial fibrillation (AF) and ventricular tachycardia are absent, the second stage of the test begins. Patients with BR, HR and ECG parameters that do not match the specified values are prescribed the infusion of levosimendan at the minimum supporting dosage of 0.05 mcg/kg/min. Second stage involves introduction of loading bolus of 4 mcg/kg of levosimendan for 10 minutes which is equal to 2/3 of the standard values and if BP is not less than 100 mm Hg, HR is not more than 100 beats per minute and paroxysmal atrial fibrillation and ventricular tachycardia are absent, the third stage of the test begins. Patients with BR, HR and ECG parameters that do not match the specified values are prescribed the infusion of levosimendan at the minimum supporting dosage of 0.1 mcg/kg/min. Third stage involves introduction of loading bolus of 4 mcg/kg of levosimendan for 10 minutes which is a standard recommended dose of 12 mcg/kg and if BP is not less than 100 mm Hg, HR is not more than 100 beats per minute and paroxysmal atrial fibrillation and ventricular tachycardia are absent, an optimum supporting dose of levosimendan in an amount of 0.15 mcg/kg/min for 27-34 hours is introduced until the total dose of levosimendan equalling is achieved 12.5 mg.

EFFECT: method enables higher effectiveness of treatment of acute cardiac failure ensuring considerable reduction of the hospital and remote lethality during 12 months of observation, frequency and severity of coronary insufficiency, chronic heart failure advance, rate of complications during the period of drug administration.

1 cl, 4 tbl, 3 ex

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RU 2 601 666 C1

Authors

Tepljakov Aleksandr Trofimovich

Tarasov Nikolaj Ivanovich

Grakova Elena Viktorovna

Sinkova Margarita Nikolaevna

Isakov Leonid Konstantinovich

Sinkov Maksim Alekseevich

Pepeljaeva Tatjana Vasilevna

Dates

2016-11-10Published

2015-08-27Filed