METHOD OF PRODUCING N-NITROSO-N2-CHLOROETHYL)CARBAMOYL]-L-ORNITHINE Russian patent published in 2016 - IPC C07C273/18 C07C275/68 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing N^δ-nitroso-N^δ-[(2-chloroethyl) carbamoyl]-L-ornithine of formula 1, having anti-tumour activity. According to disclosed method N^δ-nitroso-N^δ-[(2-chloroethyl)carbamoyl]-L-ornithine is obtained from a mixture of isomers N^δ-nitroso-N^δ-[(2-chloroethyl) carbamoyl]-L-ornithine and N^δ-[(2-chloroethyl)-N-nitrosocarbamoyl]-L-ornithine, wherein solution of mixture of isomers in water is held for 50 hours at +37 °C, reaction mass is concentrated and held for 8 hours at +8 °C.

EFFECT: disclosed method does not require complex implementation and allows in one cycle to obtain a considerable amount of target product.

1 cl, 1 dwg, 1 tbl, 1 ex