METHOD OF PREPARING N-(2-CHLOROETHYL)-N-NITROSO-L-HOMOCITRULLINE OR N-(2-CHLOROETHYL)-N-NITROSO-L-HOMOCITRULLINE FOR INJECTIONS Russian patent published in 1998 - IPC

Abstract RU 2111742 C1

FIELD: pharmaceutical technology. SUBSTANCE: compound N^ω-(2-chloroethyl)-N^ε-nitroso-L-homocitrulline or N^ω-(2-chloroethyl)-N^ω,ε-nitroso-L-homocitrulline is dissolved in solvent cooled to (+2)-(+5) C at ratio 1:25. Solvent consists of 15-25 g urea and additional components - 4-6 g polyvinylpyrrolidone (molecular mass is 12000-35000 Da) or dextran (molecular mass is 40000-60000 Da), 0.8-0.9 g glutamic acid, 5-6 g mannitol and 88-92 g water for injection. This invention relates to lyophilized form of new antitumor preparation nitrullin, derivative of nitrosoalkylureas, from alkylating compounds class. EFFECT: elimination of adverse effect at chemotherapy. 3 dwg

Similar patents RU2111742C1

Title	Year	Author	Number
N-NITROSO-N-[(2-CHLOROETHYL)CARBAMOYL]-L- ORNITHINE	2012	Krasnov Viktor Pavlovich Levit Galina L'Vovna Matveeva Tat'Jana Viktorovna Baryshnikov Anatolij Jur'Evich Baryshnikova Marija Anatol'Evna Saprykina Nina Semenovna Charushin Valerij Nikolaevich	RU2503657C1
ANTITUMOR AGENT	1980	Peretolchina N.M. Radina L.B. Gorbacheva L.B. Shishkina M.Ja. Mkrtchjan T.V. Sokolova I.A. Krasnova M.A. Sof'Ina Z.P. Belousova A.K. Nekrasova E.B. Syrkin A.B. Shulepova T.S. Singin A.S. Beljaev A.A. Krasnov V.P. Levit G.L. Tarasov A.I. Kljuchanskaja N.V. Perevodchikova N.I. Petukhova I.N. Zimakova N.I.	SU1834006A1
METHOD OF PRODUCING SEPARATE N -NITROSO- N -[(2-CHLOROETHYL) CARBAMOYL]-L-LYSINE AND N -[(2-CHLOROETHYL)-N-NITROSOCARBAMOYL]-L-LYSINE	2008	Grishakov Aleksandr Nikolaevich Krasnov Viktor Pavlovich Levit Galina L'Vovna Beljavskij Aleksandr Vladimirovich Matveeva Tat'Jana Viktorovna Tumashov Andrej Arturovich	RU2408576C2
ANTITUMOR AGENT	1996	Oborotova N.A. Polozkova A.P. Klochkova T.I. Markova-Javorskaja N.P. Kikot' B.S. Ignat'Eva E.V. Syrkin A.B. Mikhajlova L.M.	RU2093158C1
METHOD OF PRODUCING N-NITROSO-N2-CHLOROETHYL)CARBAMOYL]-L-ORNITHINE	2015	Krasnov Viktor Pavlovich Levit Galina Lvovna Musijak Vera Vasilevna Matveeva Tatjana Viktorovna Tumashov Andrej Arturovich Shprakh Zoja Sergeevna Charushin Valerij Nikolaevich	RU2601753C1
ANTITUMOR AGENT	1998	Polozkova A.P. Oborotova N.A. Lopatin P.V. Chel'Tsov-Bebutov P.A. Syrkin A.B.	RU2128042C1
3-OR-DI-(2-CHLOROETHYL)-AMINO-CONTAINING II α-ACYL-(HYDR)- -OXYSTEROIDS SHOWING ANTITUMOR ACTIVITY	1998	Rzheznikov V.M. Golubovskaja L.E. Minajlova O.N. Smirnova Z.S. Osetrova I.P. Sushinina L.P. Titova T.A. Tolkachev V.N.	RU2139292C1
METHOD OF PREPARING COMPLEX OF 1-(2'-HYDROXYETHYL)-2-METHYL-5-NITROIMIDAZOLE WITH POLYVINYLPYRROLIDONE	2001	Rozinova L.G. Lopyrev V.A. Kuznetsova Eh.Eh. Kogan A.S. Grigor'Ev E.G.	RU2205841C2
COMPLEX OF 1-(2-HYDROXYETHYL)-2-METHYL-5-NITROIMIDAZOLE WITH POLYVINYLPYRROLIDONE, METHOD OF ITS PREPARING AND PHARMACEUTICAL COMPOSITION SHOWING ANTIBACTERIAL EFFECT	1998	Lopyrev V.A. Rozinova L.G. Protsuk N.I. Grigor'Ev E.G. Kogan A.S. Kuznetsova Eh.Eh. Astakhova A.V. Mikhalev B.V. Tarasov N.V. Kamyshanov A.V.	RU2157384C2
ANTI-TUMOUR PREPARATION	2014	Sanarova Ekaterina Viktorovna Lantsova Anna Vladimirovna Baryshnikova Marija Anatol'Evna Oborotova Natalija Aleksandrovna Orlova Ol'Ga L'Vovna Polozkova Alevtina Pavlovna Krasnov Viktor Pavlovich Ignat'Eva Elena Vladimirovna Smirnova Zoja Sergeevna Levit Galina L'Vovna Musijak Vera Vasil'Evna Nikolaeva Ljudmila Leonidovna	RU2569729C1

RU 2 111 742 C1

Authors

Khajdukov Eh.Ja.

Peretolchina N.M.

Dates

1998-05-27—Published

1995-06-28—Filed