METHOD OF PRODUCING N-[5-(3,5-DIFTORBENZIL)-1H-INDAZOLE-3-YL]-4-(4-METHYLPIPERAZINE-1-YL)-2-(TETRAHYDROPYRAN-4-YLAMINO)BENZAMIDE Russian patent published in 2016 - IPC C07D405/12 A61K31/497 A61P35/00 

Abstract RU 2602071 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to novel crystalline forms of N-[5-(3,5-diftorbenzil)-1H-indazole-3-yl]-4-(4-methylpiperazine-1-yl)-2-(tetrahydropyran-4-ylamino)benzamide (Formula 1), namely forms 1 and 2, synthesis methods thereof, as well as to pharmaceutical compositions containing them.

EFFECT: invention can be used as ALK inhibitor in treating the diseases caused by deregulated kinase activity.

16 cl, 8 dwg, 4 tbl, 7 ex

(I)

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RU 2 602 071 C2

Authors

Barbudzhan Natale Alvaro

Forino Romualdo

Orsini Paolo

Dates

2016-11-10Published

2013-05-22Filed