METHOD OF PRODUCING METHYL FORMATE, TRACED WITH STABLE CARBON ISOTOPE C Russian patent published in 2016 - IPC C07C69/06 C07C67/08 C07C51/12 C07C53/10 C07B59/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to fine organic synthesis, synthesis of medical preparations and method of producing methyl formate with stable carbon isotope ¹³C, used for producing diagnostic preparations used in medical diagnosis of diseases. Method of producing methyl formate, traced with stable carbon isotope ¹³C, includes production of sodium formate, traced with carbon isotope ¹³C by processing of preliminarily prepared solution of sodium hydroxide in methanol with concentration close to saturation with carbon isotope monoxide at temperature 80-120 °C and pressure 1.5…2.5 MPa for 2…2.5 hours, sequential mixing of obtained sodium formate, traced with carbon isotope with excess of methanol and excess of concentrated sulfuric acid; then mixture is boiled for 1.5…2 hours, and then methyl-formate, traced with carbon isotope ¹³C, is extracted.

EFFECT: this technology allows to obtain a high degree of carbon isotope binding under sufficiently mild conditions of treatment with high output of the corresponding sodium formate and with low losses of expensive carbon isotope oxide.

1 cl, 4 ex