METHOD FOR PREPARING SATURATED ALIPHATIC CARBOXYLIC ACIDS AND METHODS FOR PREPARING THEIR DERIVATIVES (VARIANTS) Russian patent published in 2007 - IPC C07C51/14 C07C53/126 C07B59/00 C07C51/41 C07C67/08 C07C69/10 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of saturated aliphatic carboxylic acids with stable carbon isotopes (1-¹³C). Method involves the hydrocarboxylation reaction of α-olefins with carbon monoxide (¹³CO) and water at temperature 100-170°C and under pressure not exceeding 5 MPa in the presence of a solvent and catalytic system containing palladium compound as complex PdCl₂(PPh₃)₂ and triphenylphosphine PPh₃ taken in the ratio from 1:2 to 1:100, respectively. Synthesized carboxylic acids can be used as diagnostic test-preparations in medicine practice and in criminology, scientific investigations and in other fields. Invention provides synthesis of enanthic acid and caprylic acid labeled by stable carbon isotope ¹³C at position 1 for a single step, to increase yield of acids as measured for isotope raw, to decrease cost price of acids and to obtain derivatives of (1-¹³C)-caprylic acid - (1-¹³C0-caprylate sodium and (carboxy-¹³C)-trioctanoine.

EFFECT: improved methods of synthesis.

9 cl, 6 ex