FIELD: medicine.
SUBSTANCE: inventions refer to the new inhibitors of hepatitis B virus replication, representing 1,1-dioxo-1,4-dihydro-2H-benzo[1,2,4]thiadiazin-3-ones of general formula 1, their pharmaceutically acceptable salts and/or hydrates. In general formula
wherein Ar1 and Ar2 represent phenyl optionally substituted by one, two or three identical or different substitutes specified in C1-C4alkyl, methoxyl, halogen, carboxyl and carbonitrile. The invention also refers to the pharmaceutical composition in the form of tablets, capsules or injections placed in a pharmaceutically acceptable pack and applicable for treating hepatitis B, and the method of preventing or treating hepatitis B.
EFFECT: higher efficacy of using the compounds.
6 cl, 1 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED INDOLES, ANTIVIRAL ACTIVE COMPONENT, SYNTHESIS AND APPLICATION METHOD | 2010 |
|
RU2436786C1 |
| ANTIVIRAL ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION, MEDICINAL AGENT, METHOD OF TREATING VIRAL DISEASES | 2009 |
|
RU2407738C1 |
| HEPATITIS VIRUS PENETRATION INHIBITOR AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF HEPATITIS | 2017 |
|
RU2662161C1 |
| FLUORINE-SUBSTITUTED (3R,4R,5S)-5-GUANIDINO-4-ACYLAMINO-3-(PENTAN-3-YLOXY)CYCLOHEXENE-1-CARBOXYLIC ACIDS, ESTERS THEREOF AND METHOD OF APPLICATION | 2012 |
|
RU2489422C1 |
| HEPATITIS B (HBV) INHIBITOR | 2017 |
|
RU2666727C1 |
| ALKYL2-{[(2R,3S,5R)-5-(4-AMINO-2-OXO-2H-PYRIMIDINE-1-YL)- -HYDROXY- TETRAHYDRO-FURAN-2-YLMETHOXY]-PHENOXY-PHOSPHORYLAMINO}-PROPTONATES, NUCLEOSIDE INHIBITORS OF RNA-POLYMERASE HCV NS5B, METHODS FOR PRODUCING AND USING THEM | 2013 |
|
RU2534613C2 |
| SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-a]PYRIMIDINE-2,6-DIAMINES, SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS OF PRODUCING AND USING SAID COMPOUNDS | 2010 |
|
RU2421456C1 |
| SUBSTITUTED 3,5-DIAMINO-4-SULFONYL-PYRAZOLES AND 2-AMINO-3-SULFONYL-PYRAZOLO-[1,5-a]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT RECEPTORS, METHODS FOR THEIR PRODUCTION AND USE | 2008 |
|
RU2376291C1 |
| HEPATITIS B VIRUS (HBV) INHIBITOR | 2019 |
|
RU2726456C1 |
| SUBSTITUTED (2R,3R,5R)-3-HYDROXY-(5-PYRIMIDIN-1-YL)TETRAHYDROFURAN-2-YLMETHYL ARYL PHOSPHORAMIDATES | 2013 |
|
RU2553996C1 |
