FLUORINE-18 AND CARBON-11 LABELED RADIOLIGANDS FOR POSITRON EMISSION TOMOGRAPHY (PET) IMAGING FOR LRRK2 Russian patent published in 2018 - IPC A61K51/04 A61K101/00 C07D239/48 C07D407/12 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine, in particular to a method for visualizing positron emission tomography (PET) LRRK2 in an object tissue, according to which: a compound of formula I I where m is 0 or 1; X is -NH; R¹ is C_1-6 alkyl, C_3-6 cycloalkyl; R² is a halo-C_1-6 alkyl; R³ is -OR⁴; R⁴ is C_1-6 alkyl; halo-C_1-6 alkyl; n is 0 or 1; R⁵ and R⁶ together with the nitrogen atom to which they are attached, form morpholine; and R⁷ is a halo; or a pharmaceutically acceptable salt thereof, wherein the compound comprises at least one C¹¹ or F¹⁸ label; allow the compound to penetrate into the tissue of the object and collect a PET image of the CNS tissue or brain. Also, a group of inventions refers to a method for visualizing PET LRRK2 in a CNS tissue or brain of an object, to compounds of formula I, to the use of compounds of formula I for the preparation of a diagnostic imaging composition LRRK2 and the use of the compounds of formula I for diagnostic imaging of LRRK2.

EFFECT: group of inventions provides an expansion of the arsenal of tools for the PET method.

22 cl, 4 dwg, 3 ex, 2 tbl