FIELD: medicine.
SUBSTANCE: present invention relates to immunology. Antibody and its antigen-binding fragment are proposed, binding to human CD70, which are characterized by amino acid sequences of CDR variable domains of heavy and light chains. Extracted polynucleotide, coding antibody or antigen-binding fragment according to invention, as well as expression vector, host cell, cell-free expression system and method of producing antibody or its antigen-binding fragment, according to the invention are disclosed. Pharmaceutical composition, method of tumor cell growth inhibiting and method of exhaustion of CD70-expressing cells in patient are also disclosed.
EFFECT: present invention can find further application in therapy and diagnosis of diseases, namely cancer and autoimmune diseases characterized by CD70 expression.
27 cl, 24 dwg, 29 tbl, 21 ex
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