LIVE VACCINE FOR PREVENTING INFLUENZA AND PREPARATION METHOD THEREOF Russian patent published in 2016 - IPC A61K39/145 A61K47/06 A61K47/12 A61P31/16 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to immunology, and is designed to manufacture liquid form influenza vaccine. Live vaccine in liquid form for preventing influenza includes flu strains of type H1N1 H3N2, B and a stabilizer. Stabilizer is represented by a complex consisting of gelatin, disodium salt of ethylenediamine tetraacetic acid with maltose, at the following content in a 0.5 mg dose: flue strain of subtype H1N1 and H3N2 with specific activity of not less than 10^6.9 EID₅₀; flue strain of type B with specific activity of not less than 10^6.4 EID₅₀; gelatine - 4.5-5.5 mg; disodium salt of ethylenediamine tetraacetic acid - 0.045-0.055 mg; maltose - 0.45-0.55 mg. Group of inventions also relates to a method for producing the said influenza vaccine.

EFFECT: use of this group of inventions enables to obtain a live influenza vaccine in liquid form with high degree of purification from ovalbumin and impurity proteins, as well as promotes preservation of specific activity of vaccine during storage.

2 cl, 2 tbl