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(19)

(11)

2 605 096

(13)

(51)

IPC

C07D471/04(2006-01-01)

A61K31/437(2006-01-01)

A61P25/28(2006-01-01)

(21) (22)

Application

2014112931/04, 2012-10-04

(24)

Start date

2012-10-04

(22)

Actual filing date

2012-10-04

(45)

Published

2016-12-20

(72)

Inventor

Norimine JosikhikoTakeda KunitosiKhagivara KodziSuzuki JuitiIsikhara JukiSato Nobuaki

(73)

Holder

Ejsaj Arenddi Menedzhment Ko., Ltd.

PIRAZOLOQINOLINE DERIVATIVE Russian patent published in 2016 - IPC C07D471/04 A61K31/437 A61P25/28

Abstract RU 2605096 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to composition presented by formula (I) or its pharmaceutically acceptable salt, where R¹ is hydrogen atom; R² is aromatic ring group defined in claim, R³ is hydrogen or fluorine atom, R⁴ is hydrogen atom; R⁵ is oxepanyl group, etc.; R⁶ is hydrogen atom. Disclosed composition exhibits PDE9-inhibiting action. Therefore, intracerebral proteins concentration increase is possible. PDE9-inhibitory action and cGMP increase leads to improvement of training course and memory development.

EFFECT: composition of formula (I) can be used as therapeutic agent against cognitive dysfunctions accompanying Alzheimer's disease.

19 cl, 1 dwg, 12 tbl, 63 ex

(I)

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RU 2 605 096 C2

Authors

Norimine Josikhiko

Takeda Kunitosi

Khagivara Kodzi

Suzuki Juiti

Isikhara Juki

Sato Nobuaki

Dates

2016-12-20—Published

2012-10-04—Filed