FIELD: medicine.
SUBSTANCE: invention refers to medicine and concerns liquid pharmaceutical composition applicable for oral administration, which involves suspension of effective amount of micronized 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (nitizinone) and buffer based on citric acid with pH in range from 2.5 to 3.5. Said composition is used for treating disorders and diseases, in which inhibition of 4-hydroxyphenylpyruvate dioxygenase (HPPD) is desirable, for example, genetic tyrosinemia type I.
EFFECT: invention provides stable liquid composition of nizitinone, which is adapted for introduction in children.
20 cl, 7 ex, 12 tbl
