METHOD FOR QUANTITATIVE DETERMINATION OF METOCLOPRAMIDE Russian patent published in 2016 - IPC G01N33/52 G01N33/15 

FIELD: chemistry.

SUBSTANCE: invention relates to analytical chemistry and concerns a method for quantitative determination of metoclopramide in medicinal forms, water and biological fluids. Proposed method comprises adding to an analysed sample 20 g of ice, 1 cm³ of 0.1 % aqueous sodium nitrite solution and 1 drop of 36 % hydrochloric acid solution. Solution of chromotropic acid obtained by dissolving 0.04 g chromotropic acid in 20 cm³ water is added with addition of 1-2 into sodium carbonate grain and 20 g of ice. Further, method comprises adding 2 cm³ of 0.5 % aqueous sodium hydroxide solution, bringing volume of azo compounds to 100 cm³, photometry at wave length 520 nm. When determining metoclopramide in tablets, tablet of preparation is dispersed in water, when determining metoclopramide in urine in 50 cm³ urine is added 0.1 cm³ 10 % trichloracetic acid solution and centrifuged.

EFFECT: use of method provides high-accuracy of determination of metoclopramide in different substances.

1 cl, 3 tbl, 2 dwg, 3 ex