QUINOLONE COMPOUND AND PHARMACEUTICAL COMPOSITION Russian patent published in 2015 - IPC C07D215/22 C07D215/28 C07D401/04 C07D401/06 C07D401/10 C07D401/12 C07D407/04 C07D407/12 C07D409/04 C07D471/04 C07D493/04 A61K31/4741 A61K31/4745 A61K31/506 A61P25/28 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to organic chemistry, namely to new quinolin-4-one derivatives of formula (1) or to its pharmaceutically acceptable salt, wherein R₁ represents: (1) hydrogen, (2) C1-C6 alkyl, (35) carbamoyl-C1-C6 alkyl optionally containing morpholinyl-C1-C6 alkyl, or (36) phosphonoxy-C1-C6 alkyl optionally containing one or two C1-C6 alkyl groups on a phosphonoxy group; R₂ represents: (1) hydrogen or (2) C1-C6 alkyl; R₃ represents phenyl, thienyl or furyl, wherein a phenyl ring presented by R₃, can be substituted by one C1-C6 alkoxy group; R₄ and R₅ are bound to form a group presented by any of the following formulas: , , , , , , or a group presented by the following formula: a group optionally containing one or more substitutes specified in a group consisting of C1-C6 alkyl groups and oxogroups; R₆ represents hydrogen; and R₇ represents C1-C6 alkoxy group. The invention also refers to a pharmaceutical composition based on the compound of formula , to a preventive and/or therapeutic agent based on the compound of formula (1), using the compound of formula (1), a method for preparing the compound of formula , as well as to specific compounds.

EFFECT: there are prepared new quinolin-4-one derivatives effective in treating neurodegenerative diseases, diseases caused by neurological dysfunction, or diseases caused by mitochondrial dysfunction.

18 cl, 1 tbl, 257 ex