FIELD: pharmaceutics.
SUBSTANCE: invention relates to pharmaceutics, namely to methods of nifedipine dissolution in water medium using nanotechnology, as well as pharmaceutical compositions containing nifedipine poorly soluble in water medium, and to methods for quantitative determination of nifedipine in solution. Method of nifedipine dissolution in water medium involves preparation of aqueous solution containing nifedipine, poloxamer 407, macrogol 400, poloxamer 188 at temperature 20–37 °C. Present invention provides dissolution of nifedipine to concentration of about 0.8–4.0 mg/g, that more than 100 times exceeds limits of given substance solubility in water.
EFFECT: invention provides method of quantitative determination of nifedipine in water solution containing given modes and stages.
4 cl
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