NEW POLYETHYLENE GLYCOL-CONTAINING GLYCEROLIPID Russian patent published in 2019 - IPC A61K49/00 A61K49/08 A61K49/12 A61K47/50 A61K47/54 C08G65/00 C08G65/333 B82B3/00 

FIELD: chemistry; biotechnology.

SUBSTANCE: invention refers to chemistry, biotechnology, medicine and chemical-pharmaceutical industry. Disclosed is a polyethylene glycol-containing glycerolipid of formula (1):

,

where PEG is a chain of polyethylene glycol with molecular weight from 750 Da to 2,000 Da. Also disclosed is a conjugate of said glycerolipid with upconversion nanoparticles of NaYF₄:Yb³⁺:Er³⁺/NaYF₄ or NaYF₄:Yb³⁺:Tm³⁺/NaYF₄, coated with oleic acid residues, and a method of producing such a conjugate, according to which a solution of polyethylene glycol-containing glycerolipid in chloroform is added to a suspension of upconversion nanoparticles in hexane, then the obtained mixture is evaporated to dryness and dried in vacuum for 1–3 hours.

EFFECT: technical result is to expand the range of polyethylene glycol-containing glycerolipids and their conjugates with upconversion nanoparticles, as well as providing biocompatibility and solubilization of hydrophobic upconversion nanoparticles in biological media and increasing circulation time thereof in blood flow.

3 cl, 2 dwg, 6 ex