AZADECALINS CONDENSED WITH HETEROARYLKETONES - GLUCOCORTICOID RECEPTOR MODULATORS Russian patent published in 2017 - IPC C07D471/04 C07D498/04 A61K31/4745 A61K31/497 A61K31/506 A61K31/5377 A61K31/5383 A61P25/24 A61P3/04 A61P9/12

Abstract RU 2639867 C2

FIELD: medicine.

SUBSTANCE: invention provides azadecalin compounds of formula

ondensed with heteroarylketones, which are modulators of glucocorticoid receptors. The radicals and symbols in formula I have the definitions given in the claims. In some embodiments of the present invention, pharmaceutical composition is provided comprising a pharmaceutically acceptable excipient and a compound of formula (I). In some embodiments of the present invention, a method is provided for modulation of glucocorticoid receptors that comprises glucocorticoid receptors contacting with a compound of formula I, thereby modulating the glucocorticoid receptors, as well as a method for treatment of diseases by glucocorticoid receptors modulation, which comprises administration of a therapeutically effective amount of a formula I compound to a subject in need thereof, as a result, disease treatment takes place.

EFFECT: increased efficiency of treatment.

24 cl, 2 dwg, 1 tbl, 22 ex

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RU 2 639 867 C2

Authors

Khant Khejzel

Dzhonson Toni

Rej Nikolas

Uolters Ajejn

Dates

2017-12-25—Published

2013-05-24—Filed