COMPOUNDS FOR TREATING TRIPLE-NEGATIVE BREAST CANCER AND OVARIAN CANCER Russian patent published in 2022 - IPC A61K31/4164 A61K31/4178 A61P35/00 

Abstract RU 2776897 C2

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine and pharmacology and is aimed at treating triple-negative breast cancer. Proposed is a method for treating triple-negative breast cancer in a subject in need thereof, including administering a therapeutically effective amount of a compound represented by a structure by the formula XI(e), wherein R4 and R5 independently represent hydrogen, O-alkyl, O-haloalkyl, F, Cl, Br, I, haloalkyl, CN, -CH2CN, NH2, hydroxyl, -(CH2)iNHCH3, -(CH2)iNH2, -(CH2)iN(CH3)2, -OC(O)CF3, linear or branched C1-C5alkyl, alkylamino, aminoalkyl, -OCH2Ph, -NHCO-alkyl, COOH, -C(O)Ph, C(O)O-alkyl, C(O)H, -C(O)NH2, or NO2; i constitutes an integer from 0 to 5 and n constitutes an integer from 1 to 4, or a pharmaceutically acceptable salt, hydrate, or combination thereof, to the subject to cure triple-negative breast cancer.

EFFECT: ensured effective treatment of triple-negative breast cancer.

10 cl, 78 dwg, 2 tbl, 7 ex

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RU 2 776 897 C2

Authors

Li, Wei

Miller, Duane D

Deng, Shanshan

Krutilina, Raya

Seagroves, Tiffany

Yue, Junming

Zhao, Guannan

Qinghui, Wang

Steiner, Mitchell S.

Dates

2022-07-28Published

2019-05-15Filed