COMPOUNDS FOR TREATING CANCER Russian patent published in 2016 - IPC C07D233/66 A61K31/4164 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound presented by a structure of formula

,

wherein B represents imidazole, substituted (R₁₀)_l and R₁₁; R₁ represents O-alkyl, OH, F, Cl, Br, I or C₁-C₅ linear or branched alkyl; each R₂ and R₃ independently represents a hydrogen atom, O-alkyl, OH, F, C1, Br, I, C₁-C₅ linear or branched alkyl or -OCH₂Ph; R₅ represents F, Cl, I, -CH₃, haloalkyl, CF₃, -(CH₂)_iN(CH₃)₂ or -OCH₂Ph; each R₄ and R₆ independently represents a hydrogen atom, F, Cl, I, haloalkyl, CF₃, -(CH₂)_iN(CH₃)₂ or -OCH₂Ph; R₁₀ represents a hydrogen atom; R₁₁ represents a hydrogen atom, C₁-C₅ linear or branched alkyl, SO₂Ph, SO₂PhOCH₃ or CH₂Ph; X represents a bond; Y represents -C=O; i is equal to 0; l is equal to 1; n represents an integer from 1 to 3; and m represents an integer from 1 to 3; or its optical isomer, pharmaceutically acceptable salt or tautomer. The invention also refers to a compound presented by a structure of formula (XVI), wherein R₄ represents H, O-alkyl, I, Cl, F, alkyl, halogenalkyl, -(CH₂)_iN(CH₃)₂, OCH₂Ph or OH; R₅ represents I, Cl, F, alkyl, halogenalkyl, -(CH₂)_iN(CH₃)₂ or OCH₂Ph; R₃ represents I, Br, C1 or F; i is equal to 0; and n is equal to 1-4. The invention also refers to specific compounds. The compounds are used for producing an anti-cancer pharmaceutical composition and treating cancer, drug-resistant tumour or tumours, cancer cell disruption, wherein the above cancer, tumour or cancer cell represent cancer, tumour or cancer cell related to melanoma, metastatic melanoma or prostate cancer.

EFFECT: compounds possessing anti-cancer activity and applicable in an anti-cancer therapy (imidazole), .

18 cl, 21 tbl, 52 dwg, 28 ex