FIELD: biotechnology.
SUBSTANCE: attenuated influenza A viruses and, vectors on their basis and pharmaceutical compositions containing them are presented. The characterized attenuated influenza A virus, inducing a cross-protective response against influenza A and B virus, contains a chimeric NS fragment comprising a truncated reading frame of NS1 protein and a heterologous sequence of Nep protein gene, derived from a subtype of influenza A virus different from the subtype of said attenuated influenza A virus.
EFFECT: invention can be used to prevent or treat infectious diseases, in particular influenza, as well as for the treatment of cancer.
48 cl, 6 dwg, 3 tbl, 7 ex
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