FIELD: pharmaceutics.
SUBSTANCE: invention relates to pharmaceutics. Pharmaceutical composition for increasing salivation is described, containing multiple granules. Above granule contains core, first and second layers. Core contains cellulose polymer, silicon dioxide or sugar, selected from group, consisting of glucose, sucrose, lactose, mannitol, xylitol and sorbitol. First layer contains pilocarpine or its pharmaceutically acceptable salt. Second layer contains hydroxypropyl cellulose and ethyl cellulose in weight ratio of 1:1, wherein weight of second layer ranges from 75 % up to 250 % of granule weight before application of second layer.
EFFECT: invention provides delayed immediate release of pilocarpine from pharmaceutical composition.
10 cl, 14 tbl, 7 ex
