PHENYL DERIVATIVES AS CANNABINOID RECEPTOR 2 AGONISTS Russian patent published in 2020 - IPC C07C231/02 C07C235/46 C07C235/48 C07C237/22 C07D205/04 C07D207/10 C07D207/14 C07D209/54 C07D213/61 C07D231/12 C07D271/06 C07D277/28 C07D305/08 C07D331/04 C07D401/12 C07D403/12 C07D413/10 C07D413/12 A61K31/426 A61P9/10 A61P27/02 

FIELD: organic chemistry.

SUBSTANCE: invention relates to a compound of formula (I)

or a pharmaceutically acceptable salt thereof, wherein R¹ is cyclopropyl, C₁-C₄-alkyl or haloazetidinyl; R² is cyclopropylmethoxy, C₁-C₄-alkoxy, haloC₁-C₄-alkoxy, halopyridinyl, alkylpyrazolyl or halopyrrolidinyl; provided that at least one of R¹ and R² is cyclopropyl or cyclopropylmethoxy; R³ is -C(O)-NH-C(R⁴R⁵)-R⁶, -C(O)-R⁷ or R⁸; R⁴ and R⁵ are independently selected from hydrogen, C₁-C₄-alkyl, C₁-C₄-cycloalkyl, C₁-C₄-cycloalkyl C₁-C₄-alkyl, C₁-C₄-alkylsulfonylC₁-C₄-alkyl and C₁-C₄-alkyloxetanil; or R⁴ and R⁵ together with the carbon atom to which they are bonded, form oxetanyl or dioxothetanyl; R⁶ represents aminocarbonyl, 5-methyl-1,2,4-oxadiazol-3-yl, hydroxyC₁-C₄-alkyl, thiazolyl, C₁-C₄-alkoxycarbonyl, carboxy, difluoroazetidinylcarbonyl, 5-amino-1, 2,4-oxadiazol-3-yl, C₁-C₄-alkylaminocarbonyl or aminocarbonyl C₁-C₄-alkyl; R⁷ is (aminocarbonyl)(difluoro)pyrrolidinyl or (aminocarbonyl)azaspiro[2.4]heptyl; R⁸ is 3-C₁-C₄-alkyl-1,2,4-oxadiazol-5-yl or 5-C₁-C₄-alkyl-1,2,4-oxadiazol-3-yl. Invention also relates to a pharmaceutical composition, use and to a method for activating cannabinoid receptors 2.

EFFECT: obtaining novel organic compounds which are selective agonists of cannabinoid receptors 2.

17 cl, 74 ex