PHENYL-GUANIDINE DERIVATIVES Russian patent published in 2017 - IPC C07C279/18 C07C277/08 C07D239/42 A61K31/155 A61K31/505 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to use of a compound of formula (I) or a pharmaceutically acceptable salt thereof, or any of stereoisomeric forms thereof, or mixtures thereof for treating pathological condition mediated by Rac1 cell proteins. In formula (I) R₁ and R₁' are independently selected from a group consisting of H and CF₃ (provided that at least one of R₁ and R₁' is different from H); A is a carboxylic or heterocyclic ring system with one ring, where ring forming ring system, contains 5–7 members, where each member is independently selected from C, N and CH; or denotes an aromatic ring; wherein A substituted with one or more radicals selected from a group consisting of H, nitro, straight or branched (C₁-C₆)alkyl, halogen-(C₁-C₆)alkyl and -SO₂NR₃R₄; where each R₃ independently represents H or straight or branched (C₁-C₄)alkyl, each R₄ independently represents H or straight or branched (C₁-C₆)alkyl. Invention also relates to a compound of formula (II), method for production thereof and pharmaceutical composition containing said compound. In formula (II) A is a carboxylic or heterocyclic ring system with one ring, where ring forming a ring system contains 5–7 members, where each member is independently selected from C, N and CH; or denotes an aromatic ring.

EFFECT: disclosed compounds can be used as agents for treating fast-growing and/or resistant tumours.

14 cl, 9 dwg, 3 tbl, 7 ex

(I) (II)