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2 497 822

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IPC

C07D405/12(2006-01-01)

C07D209/32(2006-01-01)

C07D211/96(2006-01-01)

C07D213/64(2006-01-01)

C07D215/20(2006-01-01)

C07D217/16(2006-01-01)

C07D235/26(2006-01-01)

C07D249/04(2006-01-01)

C07D295/14(2006-01-01)

C07D309/14(2006-01-01)

C07D401/12(2006-01-01)

C07D295/125(2006-01-01)

A61K31/404(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2011127402/04, 2009-12-04

(24)

Start date

2009-12-04

(22)

Actual filing date

2009-12-04

(45)

Published

2013-11-10

(72)

Inventor

Branko MilanDin KhunDouehrti Dzhordzh A.Ehlmor Stiven V.Khasvol'D LizaKheksamer LauraKanzer Aaron R.Mantej Robert A.Makklellan Uill'Jam Dzh.Park Chang Kh.Park Chehol-MinPetros Ehndrju M.Sun SjaokhunSauehrs Ehndrju Dzh.Sallivan Dzherard M.Tao Chzhi-FuVan Gari T.Van LehVan SiluUehndt Majkl D.

(73)

Holder

Ehbbvi Ink.

BLC-2 SELECTIVE AGENTS CAUSING APOPTOSIS FOR TREATING CANCER AND IMMUNE DISEASES Russian patent published in 2013 - IPC C07D405/12 C07D209/32 C07D211/96 C07D213/64 C07D215/20 C07D217/16 C07D235/26 C07D249/04 C07D295/14 C07D309/14 C07D401/12 C07D295/125 A61K31/404 A61P35/00

Abstract RU 2497822 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to compounds of formula I and formula IV wherein the radical values are such as specified in cl. 1 and 4 of the patent claim, as well as to their therapeutically acceptable salts. Besides, the invention refers to a composition for treating cancer on the basis of the compounds of formula I, to using the compounds of formula I for preparing the therapeutic agent for treating cancer, as well as to using it for treating cancer.

EFFECT: there are prepared and described the new compounds which inhibit anti-apoptotic Bcl-2 and Bcl-x protein activity.

17 cl, 481 ex

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RU 2 497 822 C2

Authors

Branko Milan

Din Khun

Douehrti Dzhordzh A.

Ehlmor Stiven V.

Khasvol'D Liza

Kheksamer Laura

Kanzer Aaron R.

Mantej Robert A.

Makklellan Uill'Jam Dzh.

Park Chang Kh.

Park Chehol-Min

Petros Ehndrju M.

Sun Sjaokhun

Sauehrs Ehndrju Dzh.

Sallivan Dzherard M.

Tao Chzhi-Fu

Van Gari T.

Van Leh

Van Silu

Uehndt Majkl D.

Dates

2013-11-10—Published

2009-12-04—Filed