NEW BENZOAZEPINE DERIVATIVE AND ITS MEDICAL APPLICATION Russian patent published in 2018 - IPC C07D223/16 C07D403/10 C07D403/12 C07D403/14 C07D413/10 C07D413/12 C07D413/14 A61K31/4025 A61K31/4155 A61K31/422 A61K31/55 A61P13/00 

FIELD: pharmacology.

SUBSTANCE: invention relates to a new benzoazepine derivative of formula (I) or a pharmacologically acceptable salt thereof, wherein R¹ represents a hydroxyl group, a lower alkoxy group or , where A is absent or a lower alkylene group which may be substituted by a lower alkyl group; R⁶ represents a hydrogen atom or a lower alkyl group; R⁷ represents a hydrogen atom, a hydroxyl group, a five-membered aromatic heterocyclic group containing 3 heteroatoms selected from nitrogen and oxygen which may be substituted by a lower alkyl group, a five-membered non-aromatic heterocyclic group containing one nitrogen atom which may be substituted by an oxo group or a carbamoyl group , which may be substituted by a lower alkyl group; R² represents a hydrogen atom or a lower alkyl group; R³ is a lower alkyl group which may be substituted by 1 to 3 fluorine atoms or a halogen atom; R⁴ represents a lower alkoxy group which may be substituted by 1 to 3 halogen atoms, a five-membered aromatic monocyclic heterocyclic group or a five-membered non-aromatic monocyclic heterocyclic group (provided that each of these heterocyclic groups contains one nitrogen atom, two nitrogen atoms or one nitrogen atom and one oxygen atom in the ring, and may contain a lower alkyl group); and R⁵ represents a hydrogen atom, a lower alkyl group or a halogen atom. The invention also relates to a pharmaceutical composition based on a compound of the formula and intermediates of the formulas and .

EFFECT: new benzoazepine derivatives having V2 receptor agonist activity are obtained.

14 cl, 12 tbl, 128 ex