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(19)

(11)

2 730 498

(13)

(51)

IPC

C07D401/04(2006-01-01)

C07D401/14(2006-01-01)

C07D405/14(2006-01-01)

C07D409/14(2006-01-01)

C07D413/14(2006-01-01)

C07D417/04(2006-01-01)

C07D417/14(2006-01-01)

A61K31/4439(2006-01-01)

A61K31/4545(2006-01-01)

A61K31/4709(2006-01-01)

A61K31/498(2006-01-01)

A61K31/5355(2006-01-01)

A61K31/5377(2006-01-01)

A61P13/12(2006-01-01)

(21) (22)

Application

2018132726, 2017-02-14

(24)

Start date

2017-02-14

(22)

Actual filing date

2017-02-14

(45)

Published

2020-08-24

(72)

Inventor

Tanaka HiroakiBohno AyakoHamada MakotoIto YujiKobashi YoheiKawamura Madoka

(73)

Holder

Taisho Pharmaceutical Co., Ltd.

AZOLE-SUBSTITUTED PYRIDINE COMPOUND Russian patent published in 2020 - IPC C07D401/04 C07D401/14 C07D405/14 C07D409/14 C07D413/14 C07D417/04 C07D417/14 A61K31/4439 A61K31/4545 A61K31/4709 A61K31/498 A61K31/5355 A61K31/5377 A61P13/12

Abstract RU 2730498 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to compounds of formula [I'] or pharmaceutically acceptable salts thereof, wherein each of R², R³ and R⁴ independently denotes a hydrogen atom, a fluorine atom or methyl; W denotes a single bond, C_1-3alkanediyl or -O-CH₂CH₂-; ring A is as specified in the claim; ring B denotes any of structures of formula [IV]. Invention also relates to a pharmaceutical composition and an agent for preventing/relieving polycystic kidneys containing compounds of formula [I'].

[IV]

EFFECT: technical result is providing a compound of formula [I'], having inhibitory action on enzymes which produce 20-HETE.

15 cl, 85 tbl, 125 ex

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RU 2 730 498 C2

Authors

Tanaka Hiroaki

Bohno Ayako

Hamada Makoto

Ito Yuji

Kobashi Yohei

Kawamura Madoka

Dates

2020-08-24—Published

2017-02-14—Filed