METHOD FOR CREATION BIOLOGICAL MODEL OF SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS IN EXPERIMENT Russian patent published in 2017 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to experimental modelling. To create biological model of systemic juvenile idiopathic arthritis with characteristic systemic manifestations realized is intradermal introduction into the sole of right back paw on 0 day to male rats Wistrar at age of 8 month of 0.1 ml of solution of complete Freund adjuvant 5 mg/ml and simultaneous intraperitoneal introduction of lipopolysaccharide (LPS) solution in dose 5 mcg/kg of animal weight with the following repeated intraperitoneal introduction of LPS solution on the 18 day in dose 10 mcg/kg of animal weight and activation on 39 day of system of immunobiological supervision of organism by repeated intradermal introduction in sole of left back paw of 0.1 ml of solution of complete a Freund djuvant 5 mg/ml and simultaneous intraperitoneal introduction of LPS solution in dose 10 mcg to each animal.

EFFECT: method makes it possible to maximally approximate created model to systemic form of juvenile idiopathic arthritis in humans.