FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and concerns a multivalent immunogenic composition comprising 13 different polysaccharide-protein conjugates together with a physiologically acceptable medium, wherein each of the conjugates comprises a protein-polysaccharide capsular polysaccharide from a single serotype of Streptococcus pneumoniae, conjugated to the carrier protein CRM197, and the capsular polysaccharides are prepared from 12 serotypes, selected from the group consisting of 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F and serotype 22F or 33F. The group of inventions also relates to a pharmaceutical composition for immune response induction to the capsular polysaccharide conjugates of Streptococcus pneumoniae.
EFFECT: induction of IgG titers and functional antibodies activity that are equivalent or better compared with the Prevnar 13 vaccine for all 13 serotypes.
7 cl, 3 ex
| Title | Year | Author | Number |
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