FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, specifically to immunology, and can be used for preparing an immunogenic composition. Multivalent immunogenic composition contains 13 different polysaccharide-protein conjugates with a physiologically acceptable medium. Each of polysaccharide-protein conjugates contains capsular polysaccharide from separate serotype Streptococcus pneumoniae, conjugated with carrier protein CRM197. Capsular polysaccharides are obtained from 12 serotypes, selected from a group consisting of 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F, and serotype 2 or 9N. Group of inventions also relates to a pharmaceutical composition for inducing immune response to capsular polysaccharide conjugates Streptococcus pneumoniae.
EFFECT: use of one type of carrier protein conjugated with encapsulated polysaccharides in a multivalent vaccine enables to avoid possible immune interference.
7 cl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
POLYVALENT COMPOSITION CONTAINING PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATES | 2013 |
|
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MULTIVALENT COMPOSITION OF PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE | 2013 |
|
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INCREASE IN IMMUNOGENICITY OF STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE-PROTEIN CONJUGATES | 2018 |
|
RU2774891C2 |
IMMUNOGENIC COMPOSITIONS CONTAINING CONJUGATED CAPSULAR SACCHARIDE ANTIGENS AND USE THEREOF | 2015 |
|
RU2778704C2 |
IMMUNOGENIC COMPOSITIONS CONTAINING CONJUGATED CAPSULAR SACCHARIDE ANTIGENS AND USE THEREOF | 2015 |
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RU2687460C2 |
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|
RU2536248C2 |
Authors
Dates
2017-01-10—Published
2013-12-05—Filed