MULTIVALENT COMPOSITION BASED ON PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATES Russian patent published in 2017 - IPC A61K39/09 A61K47/48 A61P31/00 

Abstract RU 2606152 C1

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, specifically to immunology, and can be used for preparing an immunogenic composition. Multivalent immunogenic composition contains 13 different polysaccharide-protein conjugates with a physiologically acceptable medium. Each of polysaccharide-protein conjugates contains capsular polysaccharide from separate serotype Streptococcus pneumoniae, conjugated with carrier protein CRM197. Capsular polysaccharides are obtained from 12 serotypes, selected from a group consisting of 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F, and serotype 2 or 9N. Group of inventions also relates to a pharmaceutical composition for inducing immune response to capsular polysaccharide conjugates Streptococcus pneumoniae.

EFFECT: use of one type of carrier protein conjugated with encapsulated polysaccharides in a multivalent vaccine enables to avoid possible immune interference.

7 cl, 3 ex

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RU 2 606 152 C1

Authors

Park Man-Khoon

Kim Khun

Yang Zhi-Khaj

Yang Seon-Yan

No Mon-Zhi

Park Su-Dzhin

Shin Zhin-Khvan

Dates

2017-01-10Published

2013-12-05Filed