FIELD: medicine.
SUBSTANCE: group of inventions relates to immunogenic compositions for the prevention of an invasive disease caused by S. pneumoniae. Proposed compositions essentially consist of or consist of S. pneumoniae polysaccharide of serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F and 33F, each of which is conjugated with CRM197. At the same time, a conjugation reaction for S. pneumoniae of serotypes 6A, 6B, 7F, 18C, 19A, 19F and 23F is carried out in an aprotic solvent, where the aprotic solvent is DMSO, and a conjugation reaction of S. pneumoniae of serotypes 1, 3, 4, 5, 9V, 14, 22F and 33F is carried out in an aqueous solvent.
EFFECT: proposed immunogenic compositions have increased immunogenicity.
4 cl, 3 dwg, 6 tbl, 6 ex
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