METHOD OF USING 4-((1R,3S)-6-CHLORO-3-PHENYLINDANE-1-YL)-1,2,2-TRIMETHYLPIPERAZINE AND SALTS THEREOF IN TREATING SCHIZOPHRENIA Russian patent published in 2017 - IPC A61K31/4965 A61P25/18 

FIELD: medicine.

SUBSTANCE: group of inventions relates to treating central nervous system diseases. Use of 4-((1R,3S)-6-chloro-3-phenylindane-1-yl)-1,2,2-trimethylpiperazine or its salt is disclosed for treating schizophrenia, schizophreniform disorder, schizo-affective disorder, delusional disorder, short-term psychotic disorder, induced psychotic disorder or bipolar disorder, every week or twice a week in form of immediate release composition (IR-composition), long, controlled or delayed release for peroral administration in dose of 20 mg/week up to 50 mg/week in terms of free base of 4-((1R,3S)-6-chloro-3-phenylindane-1-yl)-1,2,2-trimethylpiperazine and application of 4-((1R,3S)-6-chloro-3-phenylindane-1-yl)-1,2,2-trimethylpiperazine (cikronapine) or its salt for preparing drug for above treatment.

EFFECT: introduction 1 time a week of declared dose is effective in reducing total PANSS score relative to daily administration of 10 mg; it can lead to increase of consent of patient.

10 cl, 1 dwg, 1 tbl