DIHYDROPYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE Russian patent published in 2014 - IPC C07D487/04 C07D215/233 A61K31/5025 A61P35/00 A61P9/10 A61P29/00 A61P9/00 

FIELD: chemistry.

SUBSTANCE: claimed invention relates to field of organic chemistry, namely to novel compound of formula (I), where Y and Z, each independently, are selected from group, consisting of: a) phenyl, if necessary substituted with 1 or 2 R₆; b) pyridine, imidazole, thiazole, furan, triazole, quinoline or imidazopyridine, if necessary substituted with 1 R₆; and c) substituent, independently selected from group, consisting of hydrogen, C₁-C₆alkyl or pyperidine; R₁, R₂ and R₃, each independently selected from group, consisting of hydrogen and halogen; A and B is each independently selected from hydrogen, OH and C₁-C₆alkyl; R_A and R_B are independently selected from group, consisting of hydrogen, C₁-C₆alkyl and C₃-C₈cycloalkyl; or R_A and R_B together with atom, to which they are attached, form 4-6-membered heterocycle, if necessary having additionally one heteroatom or functional heterogrpoup, selected from group, consisting of -O-, -NH, -N(C₁-C₆-alkyl)- and -NCO(C₁-C₆-alkyl)-, and 6-membered heterocycle can be additionally substituted with one or two C₁-C₆-alkyl groups; R₄ and R₅, each stands for hydrogen; and each R₆ is selected from Br, Cl, F, I, C₁-C₆-alkyl, pyrrolidine, if necessary substituted with one C₁-C₆-alkyl, C₁-C₆alkoxy, halogen-C₁-C₆alkyl, hydroxyl-C₁-C₆alkylene, -(NR_AR_B)C₁-C₆alkylene and (NR_AR_B)carbonyl; or to its individual isomer, stereoisomer or enantiomer, or their mixture, if necessary pharmaceutically acceptable salt. Invention also relates to compound of formula (II), particular compounds of formula (I) and (II), pharmaceutical composition and industrial product based on compound of formula (I) and (II), method of treating said pathological conditions, method of obtaining formula (I) compound and to intermediate compound of formula 3.

EFFECT: novel compounds, useful as inhibitors of poly(ADP-ribose)polymerase, are obtained.

50 cl, 1 tbl, 159 ex