AZETIDINE COMPOUNDS, COMPOSITIONS AND THEIR USE AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE Russian patent published in 2017 - IPC C07D487/04 C07D487/10 A61K31/397 A61P13/00 A61P43/00 

FIELD: chemistry.

SUBSTANCE: invention refers to new azetidine derivatives, having soluble epoxide hydrolase (sHE) inhibitor activity. Disclosed are compounds of formula I: R¹-L¹-A-L²-R², their stereoisomers and pharmaceutically acceptable salts, where A is selected from a group, consisting of Ia, Ib or Ic, X is N or CH₂, Y is N, CH₂, CH, L¹ is a bond, -C(O)-, -SO₂- or -(CH₂)_0-3-NR³-C(O)-; L² is a bond, -(CH₂)_1-3-, -NH-C(O)-NH-, -C(O)-, -SO₂- or -(CH₂)_0-3- NR³-C(O)-; R¹ is phenyl, where phenyl is unsubstituted or substituted with one or two R⁵, 6-member heteroaryl with two nitrogen atoms in ring, where rest of ring atoms are carbon atoms, or adamantyl; R² is phenyl, -(CH₂)_1-3-phenyl, where phenyl is unsubstituted or substituted with one or two R⁵, or 6-member heteroaryl with two nitrogen atoms in ring, where rest of ring atoms are carbon atoms; R³ is hydrogen atom; R⁴ is a hydrogen atom; R⁵ is a halogen atom, C₁-C₆-haloalkyl, C₁-C₆-haloalkoxy or -C(O)OR⁴.

EFFECT: novel chemical compounds.

13 cl, 1 tbl, 21 ex

Ia, Ib, Ic