METHOD OF PRODUCING NANOCAPSULES OF CEPHALOSPORIN ANTIBIOTICS IN HUMAN SERUM ALBUMIN Russian patent published in 2017 - IPC A61K9/51 B82B1/00 A61K31/545 A61K38/38 

Abstract RU 2619332 C2

FIELD: pharmaceutics.

SUBSTANCE: invention relates to chemical-pharmaceutical industry and is a method of encapsulating a preparation via a nonsolvent deposition method, characterized by the fact that the cores of nanocapsules are water-soluble cephalosporin antibiotics, the envelope is human serum albumin at a ratio shell: nucleus is 1:1 or 3:1, upon that the water-soluble cephalosporin antibiotics in the form of powder and preparation E472c as a surfactant is added to albumin solution, obtained mixture is stirred and after dissolving of all components one slowly, by drop, adds petroleum ether, obtained suspension of nanocapsules is filtered, washed with petroleum ether and dried.

EFFECT: invention allows to simplify and accelerate the process of producing nanocapsules and increase mass output.

1 cl, 2 dwg, 3 ex

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RU 2 619 332 C2

Authors

Krolevets Aleksandr Aleksandrovich

Bogachev Ilya Aleksandrovich

Dates

2017-05-15Published

2014-10-10Filed