FIELD: pharmacology.
SUBSTANCE: pharmaceutical composition for HIV infection treatment includes lopinavir, ritonavir in an effective amount and a polymer. At that, the pharmaceutical composition is prepared by extrusion. The composition comprises a matrix polymer consisting of PEG 6000/vinylcaprolactam/vinyl acetate of 5 to 25% by weight of the pharmaceutical composition in combination with copovidone of 45 to 65% by weight of the pharmaceutical composition. The composition is extruded at a temperature of 105 to 145°C.
EFFECT: invention allows to expand the arsenal of drugs with enhanced pharmacokinetic properties.
9 cl, 3 dwg, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PHARMACEUTICAL COMPOSITION HAVING ANTI-HIV INFECTION ACTIVITY | 2017 |
|
RU2659693C1 |
| THE METHOD OF OBTAINING A PHARMACEUTICAL COMPOSITION WITH TACROLIMUS (VARIANTS) AND A PHARMACEUTICAL COMPOSITION OBTAINED BY THESE METHODS | 2022 |
|
RU2792098C1 |
| PHARMACEUTICALLY ACCEPTABLE SOLUBILISING COMPOSITION AND PHARMACEUTICAL DOSAGE FORM CONTAINING IT | 2007 |
|
RU2469708C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING SUBSTANCE WITH ANALGESIC ACTIVITY | 2023 |
|
RU2831791C2 |
| PHARMACEUTICAL COMPOSITION FOR TREATING HIV INFECTION, METHOD FOR PREPARING IT, AND METHOD OF TREATING | 2012 |
|
RU2505286C1 |
| PHARMACEUTICAL COMPOSITION FOR TREATING HIV-INFECTION, METHOD FOR PREPARING AND METHOD OF USING | 2013 |
|
RU2543322C1 |
| EXTRUDATE WITH SODIUM MYCOPHENOLATE TO PRODUCE PERORAL SOLID DOSAGE FORM | 2018 |
|
RU2723255C2 |
| NEW ANTIRETROVIRAL COMBINATION | 2008 |
|
RU2508105C2 |
| DEVICE FOR PREPARING SOLID DISPERSION OF ACTIVE INGREDIENT | 2007 |
|
RU2448688C2 |
| PERORAL SOLID DOSAGE FORM WITH MYCOPHENOLIC ACID OR ITS SALT FOR USE AS AN IMMUNODEPRESSANT FOR TREATMENT OR PREVENTION OF ORGAN OR TISSUE TRANSPLANT REJECTION AND METHOD FOR PRODUCTION THEREOF | 2016 |
|
RU2670447C2 |
