FIELD: medicine.
SUBSTANCE: implantable naltrexone tablets and method for sterilizing implantable naltrexone tablets are described. The implantable tablet comprises naltrexone in an amount of 500-2000 mg placed in a cavity formed by moulded biodegradable polymer based on DL-lactides and/or DL-glycolides, adding Eudragit pharmaceutical polymer and a lubricant to provide controlled release of the active substance for 3 months or more. The lubricant consists of stearic acid or glyceryl monostearate to prevent tissue irritation and inflammation at the implantation site.
EFFECT: implantable naltrexone tablets, free of magnesium stearate and triamcinolone, are obtained, in order not only to reduce the metabolic load on the liver, but also reduce toxicity and carcinogenicity.
7 cl, 2 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| IMPLANTED DRUG PREPARATION OF NALTREXONE FOR TREATING ALCOHOL- OR OPIOID-DEPENDENT PATIENTS | 2012 |
|
RU2476209C1 |
| DRUG FOR TREATMENT OF PATIENTS WITH OPIUM NARCOMANIA AND METHOD OF THEIR TREATMENT | 1999 |
|
RU2147879C1 |
| IMPLANTED DEVICES FOR TREATING HIV | 2009 |
|
RU2546529C2 |
| METHODS AND COMPOSITIONS CONTAINING CLONIDINE, APPLICABLE FOR TREATING POSTOPERATIVE PAIN | 2009 |
|
RU2510263C2 |
| METHOD FOR TREATING OPIOID AND/OR ALCOHOLIC ADDICTION | 2006 |
|
RU2310449C1 |
| DRUG FOR TREATMENT OF PATIENTS WITH CHRONIC ALCOHOLISM AND METHOD OF THEIR TREATMENT | 1999 |
|
RU2147880C1 |
| IMPLANTABLE MEDICATION DISULFIRAM-BASED FOR TREATMENT OF ALCOHOL OR OPIATE-DEPENDENT PATIENT | 2012 |
|
RU2475272C1 |
| EYE IMPLANTAT PREPARED BY DOUBLE EXTRUSION METHOD | 2005 |
|
RU2389479C2 |
| COMPOUNDS CONTAINING CLONIDINE IN DEGRADABLE POLYMER | 2009 |
|
RU2494731C2 |
| RESIN COMPOSITION FOR LEUPROLIDE DELIVERY OF IMPROVED EFFECTIVENESS | 2001 |
|
RU2271826C2 |
