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2 621 037

(13)

(51)

IPC

C07D471/04(2006-01-01)

C07D231/14(2006-01-01)

C07D215/227(2006-01-01)

C07C229/56(2006-01-01)

C07F5/04(2006-01-01)

A61K31/437(2006-01-01)

A61K31/4427(2006-01-01)

A61K31/496(2006-01-01)

A61K31/506(2006-01-01)

A61K31/5377(2006-01-01)

A61P35/00(2006-01-01)

A61P11/00(2006-01-01)

A61P1/16(2006-01-01)

A61P17/06(2006-01-01)

A61P19/02(2006-01-01)

(21) (22)

Application

2014117035, 2012-09-24

(24)

Start date

2012-09-24

(22)

Actual filing date

2012-09-24

(45)

Published

2017-05-31

(72)

Inventor

Benaze AleksandrDyuklo OliveGijo NataliLassall ZhilberMasari KarimVen Valeri

(73)

Holder

Sanofi

PYRAZOLE QUINOLINONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC APPLICATION Russian patent published in 2017 - IPC C07D471/04 C07D231/14 C07D215/227 C07C229/56 C07F5/04 A61K31/437 A61K31/4427 A61K31/496 A61K31/506 A61K31/5377 A61P35/00 A61P11/00 A61P1/16 A61P17/06 A61P19/02

Abstract RU 2621037 C2

FIELD: pharmacy.

SUBSTANCE: invention relates to compounds according to formula (I)

wherein R1, R2 and R3 are as defined in claim cl. 1. The compounds of this invention are reversible and selective inhibitors of type 2 methionine aminopeptidase (MetAP2). The invention also relates to intermediates for preparing the compounds of formula (I), drug and pharmaceutical compositions based on the compounds of formula (I) and their therapeutic application.

EFFECT: increased efficiency of compounds application.

24 cl, 2 tbl, 25 ex

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RU 2 621 037 C2

Authors

Benaze Aleksandr

Dyuklo Olive

Gijo Natali

Lassall Zhilber

Masari Karim

Ven Valeri

Dates

2017-05-31—Published

2012-09-24—Filed