FIELD: pharmacology.
SUBSTANCE: application of plasma-treated silicone oil as a coating (5) in the medical injection device (1) pre-filled with a pharmaceutical composition, comprising the cylinder (2) and the piston (3) being in sliding contact inside the cylinder (2) for limiting the number of particles of the pre-visible range, having a size from 0.1 microns to 100 microns, located on the coating (5) surface and for limiting the particles of the pre-visible range, released into the pharmaceutical composition (6) contained in the injection device (1).
EFFECT: invention demonstrates high compatibility with sensitive medicinal products stored inside for a long period of time, in order to comply with the Pharmacopoeiae standards regarding the particle level in themedicinal product, yet providing favourable characteristics with respect to the sliding of the piston inside the cylinder, where the lubricant layer maintains its integrity with time.
4 cl, 6 dwg
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