FIELD: medicine.
SUBSTANCE: group of inventions relates to a method for storing an emulsion-adjuvanted vaccine in a medical injection device. This method for obtaining a medical injection device with a lubricant coating filled with an emulsion-adjuvanted vaccine includes the following steps: providing a medical injection device comprising a barrel having an inner surface; forming a silicone oil layer on at least a part of the inner surface of the barrel that is intended to be in contact with a vaccine; carrying out an oxidizing plasma treatment of said layer so as to crosslink at least part of the silicone oil layer and form a lubricant coating; filling the barrel with an emulsion-adjuvanted vaccine. Also disclosed are a medical injection device obtained by the above method and the use of an oxidizing plasma-treated silicone oil as a lubricant coating in said medical injection device.
EFFECT: group of inventions ensures the stability of an emulsion-adjuvanted vaccine in an injection device.
16 cl, 7 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| APPLICATION OF PLASMA-TREATED SILICONE OIL AS COATINGS IN MEDICAL INJECTION DEVICE | 2012 |
|
RU2621843C2 |
| LUBRICATING COATING AND MEDICAL DEVICE COMPRISING SAID COATING | 2013 |
|
RU2584421C1 |
| LUBRICATING COATING FOR MEDICAL CONTAINER | 2013 |
|
RU2590154C2 |
| PHARMACEUTICAL PACKAGING FOR OPHTHALMIC FORMULATIONS | 2016 |
|
RU2751510C2 |
| CONTAINER PRE-FILLED WITH BOTULINUM TOXIN | 2015 |
|
RU2722290C2 |
| CONTAINER PRE-FILLED WITH BOTULINUM TOXIN | 2015 |
|
RU2694820C2 |
| METHOD FOR MANUFACTURE OF DISPOSABLE INJECTION NEEDLE | 2002 |
|
RU2233675C1 |
| SYRINGE SYSTEM PRE-FILLED WITH BOTULINUS TOXIN | 2017 |
|
RU2745739C2 |
| METHOD FOR ASSESSING STABILITY OF A PROTEIN-BASED COMPOSITION | 2017 |
|
RU2732109C2 |
| PRE-FILLED PHARMACEUTICAL PACKAGE CONTAINING A LIQUID FORMULATION BASED ON A VEGF ANTAGONIST | 2016 |
|
RU2734958C2 |
