FIELD: pharmacology.
SUBSTANCE: invention relates to new compounds of formula 1, its (E)-stereoisomer or a pharmaceutically acceptable salt:
[Formula 1].
The compounds can be used to prepare pharmaceutical compositions for diseases prevention or treatment, where the disease is a "graft versus host" (GVH) response after organ transplantation or hematopoietic stem cells, multiple sclerosis, rheumatoid arthritis or lymphoneoplasia.
EFFECT: new compounds with inhibitory activity against T-cells are obtained.
8 cl, 16 tbl, 143 ex, 5 dwg
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