PIPERIDINE DERIVATIVES AS GPR119 AGONISTS Russian patent published in 2016 - IPC C07D211/22 C07D401/12 C07D401/14 C07D405/12 C07D409/12 C07D487/04 A61K31/452 A61K31/4523 A61K31/454 A61K31/4545 A61K31/497 A61K31/506 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a piperidine derivative of formula 1, stereoisomers or pharmaceutically acceptable salts thereof. Compounds of formula 1 have GPR119 agonist properties. In formula 1 [formula 1] W is O or N-R_h group; R_a, R_b and R_h each independently is H or C_1-3 alkyl group; R_c is -F or -C_1-3 hyperfluoride alkyl group; R_d and R_e are each independently selected from a group consisting of H, halogen, -C_1-5 alkyl group; or R_d and R_e are combined to form a -C_3-7 cycloalkyl group; selected from a group consisting of: , where Rf₁ and Rf₂ are each independently H, halogen or -CN group; selected from a group consisting of: , where Rk₁ and Rk₂ are each independently H, -CN Group, halogen or -C_1-5 alkyl(OH) group; is ; Q is H, -S(O)R₁ group, -S(O)₂R₁ group, -C(O)R₁ group, -C(O)OR₁ group, -C(O)NHR₁ group, -C(O)NR₂R₃ group, -S(O)₂NHR₁ group, -S(O)₂NR₂R₃ group or . Invention also relates to a pharmaceutical composition.

EFFECT: novel piperidine derivatives of formula 1, which control GPR119 activity, are obtained.

8 cl, 183 tbl, 131 ex