FIELD: pharmacology.
SUBSTANCE: proposed: a pharmaceutical combination for treating melanoma comprising: (a) 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl) pyridin-4-yl] thiazol-2-yl}amide) (S)-pyrrolidine-1,2-dicarboxylic acid (compound A) or its pharmaceutically acceptable salt; and (b), at least, one Hsp90 inhibitor, representing ethylamide 5-(2,4-dihydroxy-5-isopropylphenyl)-4-(4-morpholin-4-ylmethyl-phenyl) isoxazole-3-carboxylic acid (AUY922) or its pharmaceutically acceptable salt; the use of the said combination for manufacturing drugs to treat melanoma and corresponding method for treating melanoma.
EFFECT: synergistic effect of the compound combinations in reducing the tumour volume.
4 cl, 9 dwg, 2 tbl, 6 ex
