ANTIBODIES AND OTHER MOLECULES BINDING B7-H1 AND PD-1 Russian patent published in 2017 - IPC A61K39/395 C07K16/28 C07K16/30 

FIELD: pharmacology.

SUBSTANCE: group of inventions is described comprising an antibody or an antigen-binding fragment thereof that binds to PD-1; a humanized antibody or antigen-binding fragment thereof; a pharmaceutical composition for treatment of a disease associated with B7-H1 interaction with PD-1; a method for malignant tumour treatment in an individual, as well as a method for treatment of an infectious disease associated with the B7-H1 interaction with PD-1, wherein the above methods comprise administration of a pharmaceutical composition; application of the above antibody or antigen-binding fragment for preparation of a drug for malignant tumour treatment, as well as for preparation of a drug for treatment of an infectious disease associated with the B7-H1 interaction with PD-1; method for detection or diagnosis of a disease, disorder or infection associated with B7-H1 interaction with PD-1, method to monitor the disease, disorder or infection progression, method to monitor the response to disease, disorder or infection treatment, method for treatment of a disease associated with an increased PD-1 expression, method for treatment of diseases associated with an increased expression of B7-H1, where the methods include application of the aforementioned antibody or the antigen-binding fragment thereof.

EFFECT: invention extends the arsenal of antibodies that bind to PD-1.

37 cl, 20 dwg, 23 tbl, 7 ex