FIELD: pharmacology.
SUBSTANCE: liquid drug contains phenylephrine and an anethole analog which is substantially free of aldehyde groups, the anethole analog being selected from the group consisting of 1-methoxy-4-n-propylbenzene, methylanisate, 2-chloranethol, 2,6-dichloroanethanol, 3-nitroanethanol, 3,5-dinitroanethole, 3-cyanoanethanol, 3,5-dicyanoanethanol, 1-methoxy-3-(1-propenyl)benzene and combinations thereof. A method for determination of the phenylephrine decomposition rate involves application of an automated flow reaction and incubation control apparatus for the forced disintegration of a liquid drug using a temperature change in the range of 80°C to 140°C at a pressure of 6-7 bar for 20 minutes with fixed increments. The amount of phenylephrine in the sample is then determined and the rate of drug disintegration is determined.
EFFECT: invention allows to obtain an anis-aromatised liquid drug containing phenyphrine with a shelf life of 18 months.
12 cl, 2 tbl, 3 dwg, 14 ex
