ANTI-CLUSTERIN ANTIBODIES AND ANTIGEN-BINDING FRAGMENTS AND THEIR USE FOR TUMOURS VOLUME REDUCTION Russian patent published in 2017 - IPC C07K16/18 C12N15/13 C12N5/10 C12N15/63 A61K39/395 A61P35/00 

FIELD: biotechnology.

SUBSTANCE: clusterin-binding antibody and an antigen-binding fragment thereof are proposed. Nucleic acids encoding variable regions of antibodies, an expression vector; a cell; a kit and a method for production of an antibody or an antigen-binding fragment thereof are described. Also a pharmaceutical composition for cancer cell growth reduction or tumour cells volume reduction; combination for cancer treatment, and a pharmaceutical composition comprising a chemotherapeutic agent; a method for cancer cell growth reduction or tumour cells volume reduction; a method for carcinomas treatment; kit for application in cancer treatment or detection; use of an antibody or an antigen-binding fragment thereof for tumour volume reduction. The invention may find further application for treatment of diseases associated with clusterin.

EFFECT: antibody of the present invention is a humanized form of murine antibody 16B5 and has an approximately equal binding affinity for clusterin.

28 cl, 16 dwg, 1 tbl, 6 ex