FIELD: pharmacology.
SUBSTANCE: invention relates to an oral dosage form comprising an amorphous dispersion of {2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-3-oxo-2,3-dihydro-1H-isoindol-4-yl} amide of cyclopropanecarboxylic acid or a pharmaceutically acceptable salt thereof in a hydrophilic polymer, wherein the hydrophilic polymer is hydroxypropylmethylcellulose. Also, methods for treatment, control or prevention of various diseases such as cancer or inflammatory disease are proposed.
EFFECT: creation of a dosage form with rapid disintegration, reduced friability, content uniformity, rheological properties required for production, solubility, bioavailability, stability and desired hardness.
9 cl, 4 dwg, 2 tbl, 1 ex
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