METHOD FOR RECOMBINANT POLYPEPTIDE PRODUCTION Russian patent published in 2017 - IPC C12P21/02 A61K38/00 A61K39/395 

Abstract RU 2628310 C2

FIELD: pharmacology.

SUBSTANCE: method for antibody production, a method for production of a pharmaceutical preparation containing an antibody obtained by this method, a nucleic acid molecule, application of a vector containing such nucleic acid molecule, and application of a cell where the said nucleic acid molecule or vector is artificially introduced in the method for antibody production. This method for antibody production involves culturing a cell that expresses an antibody-enhancing sequence (APES) that has been artificially inserted into a cell and into which an exogenous DNA encoding the desired antibody was introduced to produce the desired antibody, and wherein APES is a nucleic acid molecule containing a nucleotide sequence that can bind to DNA or mRNA of NfkBia gene derived from a human, mouse, rat, or hamster by base pairing, and can suppress expression of the NfkBia gene.

EFFECT: invention allows production of an antibody at a high level with suppression of NfkBia expression.

16 cl, 29 dwg, 8 ex

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RU 2 628 310 C2

Authors

Tabuti Khisakhiro

Sugiyama Tomoya

Dates

2017-08-15Published

2012-03-30Filed