FIELD: pharmacology.
SUBSTANCE: application of (R/S)-3-amino-1-[(S)-5-phenyl-[1,2,4] oxadiazol-3-yl)-pyrrolidin-1-yl]-3-(4-fluorophenyl)-propan-1-one (with molecular mass Mr=380) in the form of hydrochloride (in terms of the salt form Mr=380+36.5 (HCl)=416.5), corresponding to the structural formula 
(I)
as dipeptidyl peptidase-4 inhibitor for treatment of type 2 diabetes mellitus.
EFFECT: chemical structure of the compound prevents its intramolecular cyclization, which preserves chemical and spatial structure in the natural conditions of the human body.
4 dwg, 1 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DIPEPTIDYL PEPTIDASE-4 INHIBITOR FOR TREATING TYPE 2 DIABETES MELLITUS, COMPOUNDS (VERSIONS) | 2018 |
|
RU2712097C1 |
| HYPOGLYCEMIC AGENT OF PEPTIDE STRUCTURE INHIBITING DIPEPTIDYL PEPTIDASE-4 | 2015 |
|
RU2600810C1 |
| AGENT OF PEPTIDE STRUCTURE, INHIBITING DIPEPTIDYL PEPTIDASE-4, AND PHARMACEUTICAL COMPOSITION BASED THEREON | 2015 |
|
RU2589258C1 |
| DIPEPTIDYL PEPTIDASE IV INHIBITING AGENT AND PHARMACEUTICAL COMPOSITION THEREOF | 2011 |
|
RU2485952C2 |
| METHYL(R)-7-[3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)-BUTYRYL]-3-TRIFLUOROMETHYL-5,6,7,8-TETRAHYDRO-IMIDAZO[1,5-a]PYRAZINE-1-CARBOXYLATE SALTS | 2010 |
|
RU2528233C2 |
| METHOD FOR IMPROVING SIGNAL TRANSFER IN ISLETS OF LANGERHANS IN DIABETES MELLITUS AND IN ITS PROPHYLAXIS | 2001 |
|
RU2261096C2 |
| NEW DIPEPTIDYL PEPTIDASE IV INHIBITORS AND USES THEREOF AS HYPOTENSIVE AGENT | 2002 |
|
RU2305553C2 |
| COMBINATION FOR REGENERATIVE THERAPY OF TYPE 1 DIABETES MELLITUS | 2018 |
|
RU2694527C1 |
| NEW SUBSTITUTED 2-CYANOPYRROLIDINES | 1999 |
|
RU2251544C2 |
| N-SUBSTITUTED 2-CYANOPYRROLIDINES | 1997 |
|
RU2180901C2 |
